We are thrilled to announce the launch of the first version of our database, a comprehensive resource focused on the annotated genomes and proteins of the gut microbiota derived from 3xTgAD Alzheimer’s disease mouse models. This database represents a major step forward in understanding the intricate relationships between gut microbiota and Alzheimer’s disease. Using cutting-edge shotgun metagenomic sequencing and advanced bioinformatic analysis, we have curated a detailed collection of species-level genome bins (SGBs), protein annotations, and functional insights. These data shed light on the microbial dynamics and functional potential of the gut microbiota in both 3xTgAD and wild-type mice at critical time points of Alzheimer’s disease progression. Key Features of the Database: • Comprehensive Genome Annotations: High-quality, manually curated annotations of genomes representing key microbial species. • Protein-Level Insights: Annotated protein sequences with functional predictions to explore gut microbial activity. • Temporal Data: Data from critical disease progression stages (2, 6, and 12 months) for detailed temporal analysis. • Comparative Analysis Tools: The ability to compare microbial features between Alzheimer’s and wild-type models. Why This Matters: Alzheimer’s disease is a complex neurodegenerative condition with growing evidence linking gut microbiota to disease progression through the gut-brain axis. Our database offers researchers a resource to explore the microbial contributions to Alzheimer’s pathology, paving the way for novel interventions and therapeutic targets. What’s Next? This is just the beginning! In future updates, we plan to incorporate: • Functional pathway annotations for deeper insights into microbial activity. • Comparative datasets from additional mouse models and human studies. • User-friendly visualization tools for enhanced data exploration. Access the Database: Researchers, bioinformaticians, and the wider scientific community can access the database here. Explore this powerful resource to uncover new insights into the role of gut microbiota in Alzheimer’s disease. We look forward to seeing how this resource accelerates research and understanding in the field. Please feel free to share your feedback and let us know how we can further support your work. Stay tuned for more updates and advancements as we continue to expand the database!